Dear Participants,

We continue diligently with the calculations. Now we are breaking through a series of protease studies to explore a new target, the RBD (receptor-binding domain) Sprot domain surface interacting with ACE2. This is the much-discussed spike protein that also contributed to the naming of coronavirus. We focus here on Sprot from the delta variant (B.1.617.2), specifically a Cryo-EM structure of Sprot with an RBD in up conformation. In comparative variant studies, we will try to determine if there is a specific discrimination upon binding of small ligands. This may help us better understand this PPI surface in further studies and even develop a small molecule probes to study these interactions.
Thank You all and we look forward to future studies together!

With best wishes,
Team SiDock@home

Hi folks! Also we added some bunches workunits with names like '%Pro_v1_run_3%' - for computations related to part of whole space of projects ligands. Main part of Sprot_delta_v1 workunits will follow by this set.

Hi folks! Also we added some bunches workunits with names like '%Pro_v1_run_3%' - for computations related to part of whole space of projects ligands. Main part of Sprot_delta_v1 workunits will follow by this set.

Sorry, should that say "will be followed by" or "will follow"? As in which comes first?

Hi Peter! Tasks "*Eprot_v1_run_3*" are being sent out now and "*Sprot*" - next set. :)