Ninth and tenth targets

Author	Message
Natalia Volunteer moderator Project administrator Project developer Project scientist Send message Joined: 9 Oct 20 Posts: 185 Credit: 2,782,517 RAC: 465	Message 1353 - Posted: 13 Nov 2021, 9:39:16 UTC Last modified: 20 Nov 2021, 11:19:45 UTC Dear participants, We have a new target which resides at a novel allosteric site on SARS-CoV-2 main protease. The site was identified by MixMD method [1] with collaboration at College of Pharmacy, University of Michigan. Target preparation was helped by Jelena Tošović (Slovenia). The two upcoming targets and results will complement the allosteric sites identified with X-ray screening by Sebastian Günther et al. [2]. The targets have good chances for wet-lab testing as soon as possible and further experimental support. (We will again temporarily pause processing of Target 5) With best wishes, Team SiDock@home [1] Phani Ghanakota and Heather A. Carlson. Moving Beyond Active-Site Detection: MixMD Applied to Allosteric Systems. The Journal of Physical Chemistry B 2016 120 (33), 8685-8695. DOI: 10.1021/acs.jpcb.6b03515 [2] Sebastian Günther et al. X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease. Science 2021 372 (6542), 642-646. DOI: 10.1126/science.abf7945 ID: 1353 · Rating: 0 · rate: / Reply Quote

Plejaden Send message Joined: 24 Oct 20 Posts: 6 Credit: 743,228 RAC: 0	Message 1355 - Posted: 13 Nov 2021, 20:15:26 UTC Congratulations ! :-) ID: 1355 · Rating: 0 · rate: / Reply Quote

Bill F Send message Joined: 3 Dec 20 Posts: 6 Credit: 1,843,848 RAC: 1,689	Message 1356 - Posted: 13 Nov 2021, 23:46:58 UTC - in response to Message 1353. Definitely ... Congratulations ID: 1356 · Rating: 0 · rate: / Reply Quote

mikey Send message Joined: 24 Oct 20 Posts: 21 Credit: 10,159,102 RAC: 0	Message 1357 - Posted: 14 Nov 2021, 3:21:00 UTC WOO HOO!!! ID: 1357 · Rating: 0 · rate: / Reply Quote

hoarfrost Volunteer moderator Project administrator Project developer Send message Joined: 11 Oct 20 Posts: 333 Credit: 25,499,310 RAC: 6,588	Message 1361 - Posted: 19 Nov 2021, 22:34:24 UTC Hi! A new version of CmDock application has been released. Progress reporting have been fixed. :) ID: 1361 · Rating: 0 · rate: / Reply Quote

Bryn Mawr Send message Joined: 16 Aug 21 Posts: 40 Credit: 17,029,368 RAC: 18,725	Message 1362 - Posted: 20 Nov 2021, 0:34:14 UTC - in response to Message 1361. Hi! A new version of CmDock application has been released. Progress reporting have been fixed. :) Wonderful, thank you. It might not have affected the function but it was very annoying. ID: 1362 · Rating: 0 · rate: / Reply Quote

Natalia Volunteer moderator Project administrator Project developer Project scientist Send message Joined: 9 Oct 20 Posts: 185 Credit: 2,782,517 RAC: 465	Message 1363 - Posted: 20 Nov 2021, 11:20:10 UTC Update: the 10th target goes in a tight bundle with the 9th :) ID: 1363 · Rating: 0 · rate: / Reply Quote

ataraxy Send message Joined: 1 Jan 21 Posts: 22 Credit: 3,532,942 RAC: 5,747	Message 1364 - Posted: 21 Nov 2021, 8:06:34 UTC - in response to Message 1361. Hi! A new version of CmDock application has been released. Progress reporting have been fixed. :) hoarfrost: Will the Linux running on ARM, hardware FP version of the application be updated as well? At the moment it is still v1.00 - see https://www.sidock.si/sidock/apps.php Thanks ID: 1364 · Rating: 0 · rate: / Reply Quote

hoarfrost Volunteer moderator Project administrator Project developer Send message Joined: 11 Oct 20 Posts: 333 Credit: 25,499,310 RAC: 6,588	Message 1366 - Posted: 21 Nov 2021, 16:46:53 UTC Hi! ARM+Linux application was updated today. :) ID: 1366 · Rating: 0 · rate: / Reply Quote

Buro87 [Lombardia] Send message Joined: 23 Nov 20 Posts: 28 Credit: 771,948 RAC: 0	Message 1369 - Posted: 22 Nov 2021, 8:29:38 UTC Congratulation to the whole Team... Well done ! ID: 1369 · Rating: 0 · rate: / Reply Quote

ataraxy Send message Joined: 1 Jan 21 Posts: 22 Credit: 3,532,942 RAC: 5,747	Message 1370 - Posted: 22 Nov 2021, 15:31:45 UTC - in response to Message 1366. Hi! ARM+Linux application was updated today. :) Thanks hoarfrost and others! I have set my Raspberry Pis to allow new work, so I'll see how it goes. ID: 1370 · Rating: 0 · rate: / Reply Quote

hoarfrost Volunteer moderator Project administrator Project developer Send message Joined: 11 Oct 20 Posts: 333 Credit: 25,499,310 RAC: 6,588	Message 1385 - Posted: 11 Dec 2021, 19:35:35 UTC Last bunch of 3CLpro_v8 tasks were sent and we return to fifth target - Eprot_v1 (run 2). Thank you for project support! ID: 1385 · Rating: 0 · rate: / Reply Quote