Targets six, seven, eight
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Targets six, seven, eight
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 NataliaSend message Joined: 9 Oct 20 Posts: 185 Credit: 2,782,517 RAC: 345    
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Dear participants, we have prepared three new targets for you! They all base on 3CLpro protein, a prime target for antiviral drug discovery because of its central involvement in virus replication. Another reason to put them high on the list is that we have a good possibility to test interesting results in a lab. The targets 6, 7 and 8 are X-ray identified allosteric sites on 3Clpro. We will make a limited number of workunits to ensure everything works fine, and then launch full-scale screening on the new targets. We will temporarily pause processing of Target 5 in favour of the new ones. With best wishes, Team SiDock@home |
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Send message Joined: 30 Oct 20 Posts: 57 Credit: 9,112,528 RAC: 0 
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I am glad that you are able to switch to more promising targets when they appear. This is no doubt still a rapidly-developing field, and everything is evolving rapidly (including the virus). |
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Send message Joined: 13 Apr 21 Posts: 7 Credit: 316,421,914 RAC: 14,661      
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Are those targets solved by AlphaFold already? How to compare Sidock to AlphaDock ? |
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Send message Joined: 30 Oct 20 Posts: 57 Credit: 9,112,528 RAC: 0
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Are those targets solved by AlphaFold already? How to compare Sidock to AlphaDock ? Where do you see that "AlphaDock" exists? AlphaFold is for protein folding, not docking. |
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Natalia Send message Joined: 9 Oct 20 Posts: 185 Credit: 2,782,517 RAC: 345
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Are those targets solved by AlphaFold already? How to compare Sidock to AlphaDock ? the AlphaFold project aims at predicting three-dimensional shapes of proteins in silico (in a computer). The results can be very useful indeed, but one needs additional information to do virtual screening. In particular, one needs to determine the potential binding site on the complex surface of the protein. Our new targets are such binding sites identified in a recent paper. The authors studied the protein as a crystal using X-rays rather than in silico. |
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Send message Joined: 24 Oct 20 Posts: 24 Credit: 1,084,026 RAC: 0
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Hello Natalia, will you ever consider to port for macOS again ? the previous versions were working fine, and then you completely stopped masOS application :( |
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Send message Joined: 26 Dec 20 Posts: 1 Credit: 199,696 RAC: 0 |
I have four units of data that have been pending upload for several days. Last upload Sep 30. Upload pending (project backoff: 04:00:00) (counting timer) any news on why this is happening? |
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Send message Joined: 11 Oct 20 Posts: 333 Credit: 25,510,012 RAC: 6,464 
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Hello! We post the news: Certificates and project communicating. |
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Natalia Send message Joined: 9 Oct 20 Posts: 185 Credit: 2,782,517 RAC: 345
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We aim to release a version for Mac OS, hopefully soon. |
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Send message Joined: 11 Oct 20 Posts: 333 Credit: 25,510,012 RAC: 6,464
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Hello folks! The last bunch of workunits for targets 6,7,8 were generated and we return to target 5 - "corona_Eprot_v1". Thank you for participation! |
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Send message Joined: 24 Oct 20 Posts: 24 Credit: 1,084,026 RAC: 0
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We aim to release a version for Mac OS, hopefully soon. Thanks for the update, hope the soon is soon :) |
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