CmDock new release pending
Dear SiDock@home community,

Just a little update on the development of our CmD software. We were planning to release CmD 0.1.5.; however, we decided to wait a bit. Namely, we want to implement a robust testing (regression, unit) pipeline and lay the work for future software optimization. Therefore we would like to implement a cross-platform consistent pseudo-random number generation that would mean - write once, compile and test everywhere... We think this can be achieved relatively quickly.

On the other front, Mac builds are being tested and we will provide the community with Mac builds through homebrew platform. We will publish the news on future release here.

All the best,
22 Jul 2022, 15:33:02 UTC · Discuss

Project status: May 2022
Dear all,

with your help, we have processed 15 targets already! It is a huge computational work, the results of which are being processed by our team and colleagues. We are working on two papers which will be available to the public as early as possible. We also continue computations for next targets. During March, April and May, project's performance was fluctuating around 250 Teraflops. We took this advantage to prioritize SARS-CoV-2 targets on top of the other research. At the end of spring 2022, we are 6426 active participants with 4493 computers.

With best wishes,
Natalia and the team of SiDock@home
31 May 2022, 19:44:33 UTC · Discuss

Project status: March 2022
Dear SiDock@home community,

Here is an update on our work. This international scientific drug
discovery project is well on its way towards its first milestone of
experimental support for the docked compounds. We are working hard
towards data processing and scientific collaborations that can help us
take our proposed compounds further. In the near future, we will prepare
a scientific write-up for You to follow.

This international drug discovery project is a wonderful example of
community, citizen science, teamwork, and contributing to the field of
medicinal chemistry with the ultimate goal of contributing to the
wellbeing of us all. Our heart goes out to all!

We also thank You for the help and support that keeps us going.
Currently, our servers reside in Russia and Slovenia. This enables us
easier task allocation and backup of the results and we hope to add a
third location with additional hardware in the future. Due to the
community request, we also plan to add official Mac and ARM64 support
for the underlying CmDock software.

Moreover, we are continuing with a new target, still from the SARS-CoV-2
pathogen, namely nsp14. It consists of the N-terminal ExoN domain
involved in proofreading and the C-terminal guanine N7 methyl
transferase (N7-MTase) domain that functions in mRNA capping and on the
latter we are focusing on now.

After this target is complete, we are turning our attention towards one
potential therapeutic target of the Ebola viral pathogen to return back
to SARS-CoV-2 after that target will be complete.

We are committed to this drug discovery project and the online
community, hope to expand and we look forward to working and discovering
new molecules and compound mechanisms of action in the future.

All health, luck, and peace to all!
Marko Jukic
14 Mar 2022, 13:58:39 UTC · Discuss

Technical maintenance on March 14th, 9:00-10:00 UTC
Dear participants,

we plan an hour-long break tomorrow, 9:00-10:00 UTC, for technical works.

All the best,
Team SiDock@home
13 Mar 2022, 16:18:05 UTC · Discuss

Project maintenance on February 26
Dear participants, new portion of project maintenance is scheduled on Ferbruary 26th, 10:00 UTC, for ~1 hour.

Thank you for participation!
26 Feb 2022, 9:02:37 UTC · Discuss

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What is SiDock@home?

Sidock@home is an international volunteer computing project aimed at drug discovery. The first mission of the project is discovery of possible drugs against the SARS-CoV-2 virus. It started as an extension of the project  COVID.SI to engage the BOINC community into the drug discovery.

You can help with your computer. With the help of BOINC, you will download a subset of compounds on your computer, examine the compounds in the context of the studied target and send the results to a server where they are collected for later analysis.

For account creation please use a Crunch_4Science invitation code. It is not needed when registering by BOINC Manager.

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